We interrogate the functional proteome to understand how genomic alterations, environmental insults, or the action of small molecule chemical probes impact individual proteins, their post-translational modifications, biochemical complexes, signaling pathways, or how these perturbations manifest en masse as phenotypic or disease signatures. Our studies are guided by specific hypotheses of biological function or through quantitative, proteome-scale mass spectrometry screens which yield data-driven entry points for further investigation.
Our research is further enabled by development of advanced chromatographic separation platforms which provide improved peptide detection and quantification, and support genome-scale interrogation of mammalian proteomes. In addition, we build open-source computation tools that facilitate interrogation of mass spectrometry data across the full spectrum of scientific inquiry, from the underlying instrumentation to interpretation of quantitative proteomic data in the context of biological pathways. Our research spans molecules, mechanisms, and markers. You can find more information on our research page.